Elevated serum levels of lysophosphatidic acid in patients with multiple sclerosis

被引：29

作者：

Balood, Mohammad ^{[1
]}

Zahednasab, Hamid ^{[1
]}

Siroos, Bahaaddin ^{[2
]}

Mesbah-Namin, Seyed Alireza ^{[1
]}

Torbati, Sara ^{[2
]}

Harirchian, Mohammad Hossein ^{[2
]}

机构：

[1] Tarbiat Modares Univ, Fac Med Sci, Dept Clin Biochem, Tehran, Iran

[2] Univ Tehran Med Sci, Iranian Ctr Neurol Res, Tehran 1419733141, Iran

来源：

HUMAN IMMUNOLOGY | 2014年 / 75卷 / 05期

关键词：

SPHINGOSINE; 1-PHOSPHATE; T-CELLS; INFLAMMATION; RECEPTORS; NEURODEGENERATION; ASSOCIATION; FINGOLIMOD; APOPTOSIS; TARGETS; PROTEIN;

D O I：

10.1016/j.humimm.2014.02.021

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

A plethora of studies have shown that lysophosphatidic acid (LPA) is involved both in inflammation and T cell apoptosis evasion. The aim of this study was to measure the concentrations of LPA in serum of patients with multiple sclerosis (MS). Twenty MS patients along with 20 age-sex matched healthy individuals were recruited for this investigation. By employment of ELISA method, we demonstrated that MS patients had higher levels of LPA in serum than control group (P = 0.006). This study is the first report of LPA elevation in MS disease. (C) 2014 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

引用

页码：411 / 413

页数：3

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