Radicals from epoxides.: Intramolecular addition to aldehyde and ketone carbonyls

被引：90

作者：

Fernández-Mateos, A ^{[1
]}

de la Nava, EM ^{[1
]}

Coca, GP ^{[1
]}

Silvo, AR ^{[1
]}

González, RR ^{[1
]}

机构：

[1] Univ Salamanca, Fac Quim, Dept Quim Organ, E-37008 Salamanca, Spain

来源：

ORGANIC LETTERS | 1999年 / 1卷 / 04期

关键词：

D O I：

10.1021/ol990699h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Titanocene chloride reacts with epoxides by C-O homolysis with clean regioselectivity. The resultant radicals undergo intramolecular addition to aldehyde and ketone carbonyls to afford cycloalkanols in good yields. The behavior of epoxy alcohols with titanocene chloride to afford saturated diols and epoxy esters that give unsaturated hydroxy esters deserve special mention.

引用

页码：607 / 609

页数：3

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