Oral iron chelators for clinical use

被引：33

作者：

Crisponi, G

Nurchi, VM

Silvagni, R

Faa, G

机构：

[1] Univ Cagliari, Dipartimento Chim & Tecnol Inorgan & Met Orga, I-09042 Cagliari, Italy

[2] Univ Cagliari, Div Anat Patol, Diparitmento Citomorfol, I-09124 Cagliari, Italy

来源：

POLYHEDRON | 1999年 / 18卷 / 25期

关键词：

iron-chelator; beta-thalassemia; deferrioxamine; iron(III);

D O I：

10.1016/S0277-5387(99)00277-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The clinical problems connected to iron overload in P-thalassemia are briefly summarized and the need for finding proper iron chelators is presented. The biological, pharmacological and clinical requirements for an ideal iron chelator are discussed. Some chemical considerations on iron chelators as well as a survey on chemical compounds tested up to now are presented. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：3219 / 3226

页数：8

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