Electroconductive nanoengineered biomimetic hybrid fibers for cardiac tissue engineering

被引：32

作者：

Allison, Shelby ^{[1
]}

Ahumada, Manuel ^{[1
]}

Andronic, Cristina ^{[1
]}

McNeill, Brian ^{[1
]}

Variola, Fabio ^{[2
]}

Griffith, May ^{[3
,4
]}

Ruel, Marc ^{[1
]}

Hamel, Veronique ^{[5
,6
]}

Liang, Wenbin ^{[5
,6
]}

Suuronen, Erik J. ^{[1
]}

Alarcon, Emilio I. ^{[1
,7
]}

机构：

[1] Univ Ottawa, Div Cardiac Surg, Inst Heart, 40 Ruskin St, Ottawa, ON K1Y 4W7, Canada

[2] Univ Ottawa, Dept Mech Engn, Ottawa, ON, Canada

[3] Univ Montreal, Maisonneuve Rosemont Hosp Res Ctr, Montreal, PQ, Canada

[4] Univ Montreal, Dept Ophthalmol, Montreal, PQ, Canada

[5] Univ Ottawa, Cardiac Elect Lab, Inst Heart, Ottawa, ON, Canada

[6] Univ Ottawa, Dept Cellular & Mol Med, Ottawa, ON, Canada

[7] Univ Ottawa, Dept Biochem Microbiol & Immunol, Ottawa, ON, Canada

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2017年 / 5卷 / 13期

基金：

加拿大自然科学与工程研究理事会; 加拿大创新基金会; 加拿大健康研究院;

关键词：

SILVER NANOPARTICLES; CARDIOMYOCYTES; PROTEIN; PROLIFERATION; SCAFFOLDS; HYDROGELS; GROWTH;

D O I：

10.1039/c7tb00405b

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

082905 [生物质能源与材料]; 100103 [病原生物学];

摘要：

We report for the first time the preparation of a fibrous material composed of surface grafted spherical nanosilver and collagen using one-step electrospinning. The resulting composite showed comparable morphology to the control without nanosilver, but had improved electrical conductivity. Under electrical stimulation, fibrous materials containing nanosilver increased connexin-43 expression and proliferation of neonatal cardiomyocytes. Furthermore, composites containing nanosilver prevented biofilm formation but did not activate macrophages.

引用

页码：2402 / 2406

页数：5

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