Synthesis and evaluation of 4-hydroxyphenylacetic acid amides and 4-hydroxycinnamamides as antioxidants

被引：33

作者：

Jung, YS

Kang, TS

Yoon, JH

Joe, BY

Lim, HJ

Seong, CM

Park, WK

Kong, JY

Cho, J

Park, NS

机构：

[1] Korea Res Inst Chem Technol, Div Med Sci, Taejon 305606, South Korea

[2] Dongguk Univ, Dept Pharmacol, Coll Med, Kyongju 780714, Kyongbuk, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 18期

关键词：

D O I：

10.1016/S0960-894X(02)00479-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

4-Hydroxyphenylacetic acid amides and 4-hydroxycinnamamides were synthesized and their antioxidant and neuroprotective activities were evaluated. Among the prepared compounds, 6f, 6g, 8b, and 9 exhibited potent inhibition of lipid peroxidation in rat brain homogenates, and marked DPPH radical scavenging activities. Furthermore, 6f, 6g, and 9 exhibited neuroprotective action against the oxidative damage induced by the exposure of primary cultured rat cortical cells to H2O2, xanthine/xanthine oxidase, or Fe2+/ascorbic acid. Based on these results, we found that 6f was the most potent antioxidant among the compounds tested. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：2599 / 2602

页数：4

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