Peroxiredoxin I (macrophage 23 kDa stress protein) is highly and widely expressed in the rat nervous system

被引：49

作者：

Mizusawa, H

Ishii, T

Bannai, S

机构：

[1] Tokyo Med & Dent Univ, Grad Sch Med, Dept Neurol & Neurol Sci, Bunkyo Ku, Tokyo 1138519, Japan

[2] Univ Tsukuba, Inst Basic Med Sci, Dept Biochem, Tsukuba, Ibaraki 3058575, Japan

来源：

NEUROSCIENCE LETTERS | 2000年 / 283卷 / 01期

关键词：

peroxiredoxin; macrophage 23 kDa stress protein; oxidative stress; Glial cell; Schwann cell; immunohistochemistry;

D O I：

10.1016/S0304-3940(00)00910-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Expression pattern of peroxiredoxin I (Prx I), a novel stress-inducible 23 kDa protein, initially found in macrophages, was investigated in the normal rat nervous system by western blot and immunohistochemistry. The protein was widely expressed in the central and peripheral nervous system, particularly in oligodendroglia and Schwann cells. Weak staining of axons and neuropil suggests neuronal processes also may contain Prx I. Immunostaining of neuronal cell bodies were not evident. Since Prx I reduces hydrogen peroxide, the widespread glial expression of Prx I indicates that it may play an important protective role against oxidative damage in the nervous system. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：57 / 60

页数：4

共 12 条

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