Left-right asymmetry: All hands to the pump

被引：4

作者：

Stern, CD ^{[1
]}

Wolpert, L ^{[1
]}

机构：

[1] UCL, Dept Anat & Dev Biol, London WC1E 6BT, England

来源：

CURRENT BIOLOGY | 2002年 / 12卷 / 23期

关键词：

D O I：

10.1016/S0960-9822(02)01312-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

How do embryos establish differences between their left and right sides? Previous studies have implicated various signaling molecules and directional beating of cilia. Now, a new player enters the scene: the proton-potassium pump.

引用

页码：R802 / R803

页数：2

共 15 条

[1]

BROWN NA, 1990, DEVELOPMENT, V109, P1

[2] Knowing left from right: the molecular basis of laterality defects [J].

Capdevila, J ;

Belmonte, JCI .

MOLECULAR MEDICINE TODAY, 2000, 6 (03) :112-118

[3] Conserved function for embryonic nodal cilia [J].

Essner, JJ ;

Vogan, KJ ;

Wagner, MK ;

Tabin, CJ ;

Yost, HJ ;

Brueckner, M .

NATURE, 2002, 418 (6893) :37-38

[4] THE ROLE OF IONIC CURRENTS IN ESTABLISHING DEVELOPMENTAL PATTERN [J].

JAFFE, LF .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1981, 295 (1078) :553-566

[5] Asymmetries in H+/K+-ATPase and cell membrane potentials comprise a very early step in left-right patterning [J].

Levin, M ;

Thorlin, T ;

Robinson, KR ;

Nogi, T ;

Mercola, M .

CELL, 2002, 111 (01) :77-89

[6] Gap junctions are involved in the early generation of left-right asymmetry [J].

Levin, M ;

Mercola, M .

DEVELOPMENTAL BIOLOGY, 1998, 203 (01) :90-105

[7] A MOLECULAR PATHWAY DETERMINING LEFT-RIGHT ASYMMETRY IN CHICK EMBRYOGENESIS [J].

LEVIN, M ;

JOHNSON, RL ;

STERN, CD ;

KUEHN, M ;

TABIN, C .

CELL, 1995, 82 (05) :803-814

[8] Determination of left-right patterning of the mouse embryo by artificial nodal flow [J].

Nonaka, S ;

Shiratori, H ;

Saijoh, Y ;

Hamada, H .

NATURE, 2002, 418 (6893) :96-99

[9] INTEGRATIVE MECHANISMS IN DEVELOPMENT OF THE EARLY CHICK BLASTODERM .1. REGULATIVE POTENTIALITY OF SEPARATED PARTS [J].

SPRATT, NT ;

HAAS, H .

JOURNAL OF EXPERIMENTAL ZOOLOGY, 1960, 145 (02) :97-137

[10] ACTIVIN AND ITS RECEPTORS DURING GASTRULATION AND THE LATER PHASES OF MESODERM DEVELOPMENT IN THE CHICK-EMBRYO [J].

STERN, CD ;

YU, RT ;

KAKIZUKA, A ;

KINTNER, CR ;

MATHEWS, LS ;

VALE, WW ;

EVANS, RM ;

UMESONO, K .

DEVELOPMENTAL BIOLOGY, 1995, 172 (01) :192-205

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