Extracellular thioredoxin and thioredoxin-binding protein 2 in control of cancer

被引：98

作者：

Nakamura, Hajime ^{[1
]}

Masutani, Hiroshi

Yodoi, Junji

机构：

[1] Kyoto Univ Hosp, Dept Expt Therapeut, Kyoto 6068507, Japan

[2] Kyoto Univ, Inst Virus Res, Dept Biol Responses, Lab Infect & Prevent, Kyoto 6068507, Japan

来源：

SEMINARS IN CANCER BIOLOGY | 2006年 / 16卷 / 06期

关键词：

thioredoxin; redox; thioredoxin-binding protein 2;

D O I：

10.1016/j.semcancer.2006.09.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Thioredoxin-1 (TRX) is a redox-active protein with multiple intracellular and extracellular functions. Intracellular redox balance is maintained by the TRX family and its related molecules. Extracellular TRX shows cytoprotective effects, while truncated Trx80 has more mitogenic activity. Exogenously administered TRX does not promote the growth of cancer in vivo and shows anti-chemotactic effect for neutrophils and antiinflammatory functions. Thioredoxin is released from cells in response to oxidative stress and TRX levels in plasma or serum are good markers for oxidative stress associated with cancer. Thioredoxin-binding protein 2 (TBP-2) is an endogenous negative regulator of TRX and a tumor suppressor. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：444 / 451

页数：8

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