Differential changes of calcium binding proteins in the rat striatum after kainic acid-induced seizure

被引：17

作者：

Lee, J

Park, K

Lee, S

Whang, K

Kang, M

Park, C

Huh, Y

机构：

[1] Kyunghee Univ, Coll Med, Dept Anat, Dongdaemun Gu, Seoul 130701, South Korea

[2] Yonsei Univ, Wonju Coll Med, Dept Neurol, Gangwon Do 220701, South Korea

[3] Yonsei Univ, Wonju Coll Med, Dept Neurosurg, Gangwon Do 220701, South Korea

来源：

NEUROSCIENCE LETTERS | 2002年 / 333卷 / 02期

关键词：

calbindin D28k; parvalbumin; calretinin; kainic acid; striatum;

D O I：

10.1016/S0304-3940(02)00987-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

It has been suggested that calcium binding proteins protect against Ca2+ overload, thus rendering neurons more resistant against excitotoxicity. The influence of kainic acid, which induces status epilepticus, on the expressions of calbindin D28k, parvalbumin and calretinin was examined in the rat striatum by immunohistochemistry and microdensitometry. At 1, 3 and 6 days after kainic acid-induced seizure, the number of calretinin-positive neurons in the striatum was significantly lower than in control rats. However, no significant difference was observed in the number of calbindin D28k- and parvalbumin-positive neurons in control and seizure rats. At 1, 3 and 6 days after seizure the optical densities of calretinin- and parvalbumin-positive neurons in the striatum were significantly lower than in control rats. Our finding concerning the selective loss of calretinin-positive neurons in seizure groups suggests that calcium binding proteins in the striatum have differential vulnerabilities to kainic acid-induced seizure. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：87 / 90

页数：4

共 24 条

[1] Neurodegenerative and morphogenic changes in a mouse model of temporal lobe epilepsy do not depend on the expression of the calcium-binding proteins parvalbumin, calbindin, or calretinin [J].