Pore-forming proteins in pathogenic protozoan parasites

被引：21

作者：

Horta, MF

机构：

[1] Dept de Bioquim. e Imunologia, Inst. de Cie. Biológicas, Universidade Federal de Minas Gerais, 31270-010 Belo Horizonte, MG

来源：

TRENDS IN MICROBIOLOGY | 1997年 / 5卷 / 09期

关键词：

D O I：

10.1016/S0966-842X(97)01109-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pore-forming proteins (PFPs) may play important roles in pathogenesis by protozoan parasites by either directly damaging the plasma membrane of the host cells or ensuring intracellular survival of the parasites by promoting their exit from lysosomal vacuoles. The Leishmania amazonensis pore-forming cytolysin, leishporin, may play a crucial role in the pathogenesis of leishmaniasis.

引用

页码：363 / 366

页数：4

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