SIRT6, a protein with many faces

被引：79

作者：

Gertler, Asaf A. ^{[1
]}

Cohen, Haim Y. ^{[1
]}

机构：

[1] Bar Ilan Univ, Mina & Everard Goodman Fac Life Sci, IL-52900 Ramat Gan, Israel

来源：

BIOGERONTOLOGY | 2013年 / 14卷 / 06期

基金：

以色列科学基金会; 欧洲研究理事会;

关键词：

SIRT6; Deacylation; Ageing; HISTONE DEACETYLASE SIRT6; LIFE-SPAN; GENOMIC INSTABILITY; STRUCTURAL BASIS; DNA-REPAIR; CELL-CYCLE; IN-VIVO; CHROMATIN; METABOLISM; INHIBITION;

D O I：

10.1007/s10522-013-9478-8

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Sirtuins are NAD(+) dependent deacylases enzymes. There are seven mammalian sirtuins, SIRT1-SIRT7, which are localized to different cellular compartments and are capable of diverse catalytic activities. SIRT6 is a key regulator of healthy ageing. In the past decade our understanding of SIRT6 significantly increased in many different aspects. We know its cellular localization, catalytic activities, substrates and the pathways it is involved in. This review discusses the recent discoveries regarding the SIRT6 enzyme.

引用

页码：629 / 639

页数：11

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