Aromatase in breast cancer tissue - Localization and relationship with reproductive status of patients

被引：22

作者：

Berstein, LM

Larionov, AA

Kyshtoobaeva, AS

Pozharisski, KM

Semiglazov, VF

Ivanova, OA

机构：

[1] NN PETROV ONCOL RES INST,DEPT PATHOL,ST PETERSBURG,RUSSIA

[2] NN PETROV ONCOL RES INST,DEPT BREAST TUMORS,ST PETERSBURG,RUSSIA

来源：

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 1996年 / 122卷 / 08期

关键词：

aromatase; breast cancer; immunohistochemistry;

D O I：

10.1007/BF01187162

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The precise place of local estrogen production in mammary cancer is still controversial. In this investigation localization of aromatase (the key enzyme of estrogen biosynthesis) was studied in breast cancer tissue by immunohistochemical method using polyclonal rabbit antibodies. The cytoplasmic staining was found in different cell types, but the most intensive specific staining was found in malignant cells and it was stronger (P<0.01) in postmenopausal patients than in patients of reproductive age.

引用

页码：495 / 498

页数：4

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