Efficacy of SCH56592 in a rabbit model of invasive aspergillosis

被引：52

作者：

Kirkpatrick, WR

McAtee, RK

Fothergill, AW

Loebenberg, D

Rinaldi, MG

Patterson, TF

机构：

[1] Univ Texas, Hlth Sci Ctr, Dept Med, Div Infect Dis, San Antonio, TX 78284 USA

[2] Univ Texas, Hlth Sci Ctr, Dept Pathol, San Antonio, TX 78284 USA

[3] S Texas Vet Hlth Care Syst, Audie Murphy Div, San Antonio, TX 78284 USA

[4] Schering Plough Corp, Inst Res, Kenilworth, NJ 07033 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 03期

关键词：

D O I：

10.1128/AAC.44.3.780-782.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

SCH56592 (SCH) was evaluated in an immunosuppressed rabbit model of invasive aspergillosis. SCH was more effective than similar doses of itraconazole and as effective as amphotericin B in the clearance of Aspergillus spp. from tissues. Compared with controls, SCH regimens reduced mortality, improved survival, and significantly reduced tissue colony counts.

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页码：780 / 782

页数：3

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