DEP domains: More than just membrane anchors

被引：38

作者：

Chen, Songhai ^{[1
]}

Hamm, Heidi E. ^{[1
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Pharmacol, Nashville, TN 37232 USA

来源：

DEVELOPMENTAL CELL | 2006年 / 11卷 / 04期

关键词：

D O I：

10.1016/j.devcel.2006.09.011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit.

引用

页码：436 / 438

页数：3

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