Exercise Training as a Treatment for Chronic Inflammation in the Elderly

被引:97
作者
Nicklas, Barbara J. [1 ]
Brinkley, Tina E. [1 ]
机构
[1] Wake Forest Univ, Bowman Gray Sch Med, Dept Internal Med, Sect Gerontol & Geriatr Med,J Paul Sticht Ctr Agi, Winston Salem, NC 27157 USA
来源
EXERCISE AND SPORT SCIENCES REVIEWS | 2009年 / 37卷 / 04期
基金
美国国家卫生研究院;
关键词
aging; sarcopenia; low-grade inflammation; cytokines; physical activity; C-REACTIVE PROTEIN; NECROSIS-FACTOR-ALPHA; INDUCED WEIGHT-LOSS; SKELETAL-MUSCLE; PHYSICAL-ACTIVITY; INTERLEUKIN-6; RECEPTOR; OLDER-ADULTS; MARKERS; ASSOCIATIONS; EXPRESSION;
D O I
10.1097/JES.0b013e3181b7b3d9
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
NICKLAS, B.J. and T.E. BRINKLEY. Exercise training as a treatment for chronic inflammation in the elderly. Exerc. Sport Sci. Rev., Vol. 37, No. 4, pp. 165-170, 2009. Persistent subclinical inflammation predisposes to chronic disease, as well as the development of sarcopenia and disability, in frail elderly. Thus, the inflammatory pathway is a potential target for interventions to reduce aging-related disease and disability. This article highlights emerging data suggesting that increasing physical activity could be effective for reducing chronic inflammation in the elderly.
引用
收藏
页码:165 / 170
页数:6
相关论文
共 35 条
[1]   Relationship between physical activity and inflammation among apparently healthy middle-aged and older US adults [J].
Abramson, JL ;
Vaccarino, V .
ARCHIVES OF INTERNAL MEDICINE, 2002, 162 (11) :1286-1292
[2]   RETRACTED: Exercise induces interleukin-8 expression in human skeletal muscle (Retracted article. See vol. 589, pg. 3407, 2011) [J].
Akerstrom, T ;
Steensberg, A ;
Keller, P ;
Keller, C ;
Penkowa, M ;
Pedersen, BK .
JOURNAL OF PHYSIOLOGY-LONDON, 2005, 563 (02) :507-516
[3]   Chronic Inflammation Is Associated With Low Physical Function in Older Adults Across Multiple Comorbidities [J].
Brinkley, Tina E. ;
Leng, Xiaoyan ;
Miller, Michael E. ;
Kitzman, Dalane W. ;
Pahor, Marco ;
Berry, Michael J. ;
Marsh, Anthony P. ;
Kritchevsky, Stephen B. ;
Nicklas, Barbara J. .
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2009, 64 (04) :455-461
[4]   Repeated bouts of aerobic exercise lead to reductions in skeletal muscle free radical generation and nuclear factor κB activation [J].
Brooks, Susan V. ;
Vasilaki, Aphrodite ;
Larkin, Lisa M. ;
McArdle, Anne ;
Jackson, Malcolm J. .
JOURNAL OF PHYSIOLOGY-LONDON, 2008, 586 (16) :3979-3990
[5]   Associations between cardiorespiratory fitness and C-reactive protein in men [J].
Church, TS ;
Barlow, CE ;
Earnest, CP ;
Kampert, JB ;
Priest, EL ;
Blair, SN .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2002, 22 (11) :1869-1876
[6]   Physical activity, exercise, and inflammatory markers in older adults: Findings from the health, aging and body composition study [J].
Colbert, LH ;
Visser, M ;
Simonsick, EM ;
Tracy, RP ;
Newman, AB ;
Kritchevsky, SB ;
Pahor, M ;
Taaffe, DR ;
Brach, J ;
Rubin, S ;
Harris, TB .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2004, 52 (07) :1098-1104
[7]   Tumor necrosis factor-α gene transfer induces cachexia and inhibits muscle regeneration [J].
Coletti, D ;
Moresi, V ;
Adamo, S ;
Molinaro, M ;
Sassoon, D .
GENESIS, 2005, 43 (03) :120-128
[8]   Muscle-derived interleukin-6: mechanisms for activation and possible biological roles [J].
Febbraio, MA ;
Pedersen, BK .
FASEB JOURNAL, 2002, 16 (11) :1335-1347
[9]   The origins of age-related proinflammatory state [J].
Ferrucci, L ;
Corsi, A ;
Lauretani, F ;
Bandinelli, S ;
Bartali, B ;
Taub, DD ;
Guralnik, JM ;
Longo, DL .
BLOOD, 2005, 105 (06) :2294-2299
[10]  
Franceschi C, 2000, ANN NY ACAD SCI, V908, P244