Relationships between cancer and aging: a multilevel approach

被引：55

作者：

Anisimov, Vladimir N. ^{[1
]}

Sikora, Ewa ^{[2
]}

Pawelec, Graham ^{[3
]}

机构：

[1] NN Petrov Oncol Res Inst, Dept Carcinogenesis & Oncogerontol, St Petersburg 197758, Russia

[2] M Nencki Inst Expt Biol, PL-02093 Warsaw, Poland

[3] Univ Tubingen, Med Res Ctr, Sch Med, Tubingen, Germany

来源：

BIOGERONTOLOGY | 2009年 / 10卷 / 04期

关键词：

Aging; Carcinogenesis; SENESCENCE-ASSOCIATED GENES; INSULIN SIGNALING PATHWAY; LIFE-SPAN EXTENSION; CELLULAR SENESCENCE; OXIDATIVE STRESS; DNA-DAMAGE; CALORIC RESTRICTION; TUMOR-CELLS; BETA-GALACTOSIDASE; NEONATAL EXPOSURE;

D O I：

10.1007/s10522-008-9209-8

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

The incidence of cancer increases with age in humans and in laboratory animals alike. There are different patterns of age-related distribution of tumors in different organs and tissues. Aging may increase or decrease the susceptibility of various tissues to initiation of carcinogenesis and usually facilitates promotion and progression of carcinogenesis. Aging may predispose to cancer in two ways: tissue accumulation of cells in late stages of carcinogenesis and alterations in internal homeostasis, in particular, alterations in immune and endocrine systems. Increased susceptibility to the effects of tumor promoters is found both in aged animals and aged humans, as predicted by the multistage model of carcinogenesis. Aging is associated with a number of events at the molecular, cellular and physiological levels that influence carcinogenesis and subsequent cancer growth. An improved understanding of age-associated variables impacting on the tumor microenvironment, as well as the cancer cells themselves, will result in improved treatment modalities in geriatric oncology.

引用

页码：323 / 338

页数：16

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