The RNA world of the nucleolus: Two major families of small RNAs defined by different box elements with related functions

被引：432

作者：

Balakin, AG ^{[1
]}

Smith, L ^{[1
]}

Fournier, MJ ^{[1
]}

机构：

[1] UNIV MASSACHUSETTS, DEPT BIOCHEM & MOL BIOL, AMHERST, MA 01003 USA

来源：

CELL | 1996年 / 86卷 / 05期

关键词：

D O I：

10.1016/S0092-8674(00)80156-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

We have discovered that all known yeast and vertebrate small nucleolar RNAs (snoRNAs), except for the MRP/7-2 RNA, fall into two major classes. One class is defined by conserved boxes C and D and the other by a novel element: a consensus ACA triplet positioned 3 nt before the 3' end of the RNA. A role for the ACA box in snoRNA stability has been established by mutational analysis of a yeast ACA snoRNA (snR11). Full function of the box depends on the integrity of an adjacent upstream stem. All members of the yeast ACA family are associated with the GAR1 protein. Binding of this or another common small nucleolar ribonucleoprotein particle protein is predicted to be a critical entry point to snoRNA posttranscriptional life, including precise formation of the snoRNA 3' end.

引用

页码：823 / 834

页数：12

共 47 条

[1]

ARIS JP, 1991, METHOD ENZYMOL, V194, P735

[2]

Ausubel FM., 1994, Curr. Protoc. Mol. Biol

[3]

BALAKIN AG, 1994, J BIOL CHEM, V269, P739

[4]

SNR31, SNR32, AND SNR33 - 3 NOVEL, NONESSENTIAL SNRNAS FROM SACCHAROMYCES-CEREVISIAE [J].

BALAKIN, AG ;

SCHNEIDER, GS ;

CORBETT, MS ;

NI, JW ;

FOURNIER, MJ .

NUCLEIC ACIDS RESEARCH, 1993, 21 (23) :5391-5397

[5]

BROWN, JW .

CELL, 1990, 62 (03) :407-409

[6]

Processing of the intron-encoded U16 and U18 snoRNAs: The conserved C and D boxes control both the processing reaction and the stability of the mature snoRNA [J].

Caffarelli, E ;

Fatica, A ;

Prislei, S ;

DeGregorio, E ;

Fragapane, P ;

Bozzoni, I .

EMBO JOURNAL, 1996, 15 (05) :1121-1131

[7]

U17(XS8), A SMALL NUCLEOLAR RNA WITH A 12 NT COMPLEMENTARITY TO 18S RIBOSOMAL-RNA AND CODED BY A SEQUENCE REPEATED IN THE 6 INTRONS OF XENOPUS-LAEVIS RIBOSOMAL PROTEIN-S8 GENE [J].

CECCONI, F ;

MARIOTTINI, P ;

LORENI, F ;

PIERANDREIAMALDI, P ;

CAMPIONI, N ;

AMALDI, F .

NUCLEIC ACIDS RESEARCH, 1994, 22 (05) :732-741

[8]

CHEN BW, 1994, BIOTECHNIQUES, V17, P657

[9]

THE RNA OF RNASE MRP IS REQUIRED FOR NORMAL PROCESSING OF RIBOSOMAL-RNA [J].

CHU, S ;

ARCHER, RH ;

ZENGEL, JM ;

LINDAHL, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (02) :659-663

[10]

SSB-1 OF THE YEAST SACCHAROMYCES-CEREVISIAE IS A NUCLEOLAR-SPECIFIC, SILVER-BINDING PROTEIN THAT IS ASSOCIATED WITH THE SNR10 AND SNR11 SMALL NUCLEAR RNAS [J].

CLARK, MW ;

YIP, MLR ;

CAMPBELL, J ;

ABELSON, J .

JOURNAL OF CELL BIOLOGY, 1990, 111 (05) :1741-1751

← 1 2 3 4 5 →