Influence of lecithin-lipid composition on physico-chemical properties of nanoliposomes loaded with a hydrophobic molecule

被引：68

作者：

Bouarab, Lynda ^{[1
]}

Maherani, Behnoush ^{[1
]}

Kheirolomoom, Azadeh ^{[2
]}

Hasan, Mahmoud ^{[1
]}

Aliakbarian, Bahar ^{[3
]}

Linder, Michel ^{[1
]}

Arab-Tehrany, Elmira ^{[1
]}

机构：

[1] Univ Lorraine, Lab Ingn Biomol, F-54504 Vandoeuvre Les Nancy, France

[2] Univ Calif Davis, Dept Biomed Engn, Davis, CA 95616 USA

[3] Univ Genoa, Dept Civil Chem & Environm Engn DICCA, I-16145 Genoa, Italy

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2014年 / 115卷

关键词：

Liposome; Cinnamic acid; Encapsulation; Antioxidant; Physico-chemical characterization; ENCAPSULATION EFFICIENCY; MEMBRANE-FLUIDITY; FATTY-ACIDS; LIPOSOME; MODEL; CHOLESTEROL; RAPESEED; DELIVERY; RELEASE; DRUGS;

D O I：

10.1016/j.colsurfb.2013.11.034

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 [生物物理学];

摘要：

In this work, we studied the effect of nanoliposome composition based on phospholipids of docosahexaenoic acid (PL-DHA), salmon and soya lecithin, on physico-chemical characterization of vector. Cinnamic acid was encapsulated as a hydrophobic molecule in nanoliposomes made of three different lipid sources. The aim was to evaluate the influence of membrane lipid structure and composition on entrapment efficiency and membrane permeability of cinnamic acid. These properties are important for active molecule delivery. In addition, size, electrophoretic mobility, phase transition temperature, elasticity and membrane fluidity were measured before and after encapsulation. The results showed a correlation between the size of the nanoliposome and the entrapment. The entrapment efficiency of cinnamic acid was found to be the highest in liposomes prepared from salmon lecithin. The nanoliposomes composed of salmon lecithin presented higher capabilities as a carrier for cinnamic acid encapsulation. These vesicles also showed a high stability which in turn increases the membrane rigidity of nanoliposome as evaluated by their elastic properties, membrane fluidity and phase transition temperature. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：197 / 204

页数：8

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