Chronic Administration of Mood Stabilizers Upregulates BDNF and Bcl-2 Expression Levels in Rat Frontal Cortex

被引：78

作者：

Chang, Yunyoung C. ^{[1
]}

Rapoport, Stanley I. ^{[1
]}

Rao, Jagadeesh S. ^{[1
]}

机构：

[1] NIA, Brain Physiol & Metab Sect, NIH, Bethesda, MD 20892 USA

来源：

NEUROCHEMICAL RESEARCH | 2009年 / 34卷 / 03期

基金：

美国国家卫生研究院;

关键词：

BDNF; Bcl-2; Lithium; Valproate; Carbamazepine; Lamotrigine; Brain; Bipolar; Disorder; Rat; CYTOSOLIC PHOSPHOLIPASE A(2); FATTY-ACID DEPRIVATION; DNA-BINDING ACTIVITY; BIPOLAR DISORDER; ARACHIDONIC-ACID; PROTEIN EXPRESSION; TEMPORAL CORTEX; BRAIN; LITHIUM; SCHIZOPHRENIA;

D O I：

10.1007/s11064-008-9817-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Brain-derived neurotrophic factor (BDNF) and B-cell lymphoma-2 (Bcl-2) proteins are neuroprotective factors involved in neuronal signaling, survival and plasticity. Both can be regulated by cyclic AMP response element binding (CREB) protein. Decreased levels of BDNF and Bcl-2 are implicated in the pathogenesis of bipolar disorder. The present study investigated whether chronically administered mood stabilizers would increase BDNF and/or Bcl-2 levels in rat brain. Real time RT-PCR, sandwich ELISA and Western blotting were used to measure BDNF and Bcl-2 mRNA and protein levels in the frontal cortex of rats chronically administered carbamazepine (CBZ) or lamotrigine (LTG) to produce plasma concentrations therapeutically relevant to bipolar disorder. Chronic CBZ and LTG significantly increased BDNF and Bcl-2 mRNA and protein levels in the frontal cortex. A common mechanism of action of mood stabilizers in the treatment of bipolar disorder may involve neuroprotection mediated by upregulation of brain BDNF and Bcl-2 expression.

引用

页码：536 / 541

页数：6

共 46 条

[1]

ABRAMSON SB, 1991, J IMMUNOL, V147, P231

[2] Effects of acute and chronic lamotrigine treatment on basal and stimulated extracellular amino acids in the hippocampus of freely moving rats [J].

Ahmad, S ;

Fowler, LJ ;

Whitton, PS .

BRAIN RESEARCH, 2004, 1029 (01) :41-47

[3] Mechanism of apoptosis in HL-60 cells induced by n-3 and n-6 polyunsaturated fatty acids [J].

Arita, K ;

Kobuchi, H ;

Utsumi, T ;

Takehara, Y ;

Akiyama, J ;

Horton, AA ;

Utsumi, K .

BIOCHEMICAL PHARMACOLOGY, 2001, 62 (07) :821-828

[4] Mood stabilizers target cellular plasticity and resilience cascades - Implications for the development of novel therapeutics [J].

Bachmann, RF ;

Schloesser, RJ ;

Gould, TD ;

Manji, HK .

MOLECULAR NEUROBIOLOGY, 2005, 32 (02) :173-202

[5] New data on the use of lithium, divalproate, and lamotrigine in rapid cycling bipolar disorder [J].

Calabrese, JR ;

Rapport, DJ ;

Youngstrom, EA ;

Jackson, K ;

Bilali, S ;

Findling, RL .

EUROPEAN PSYCHIATRY, 2005, 20 (02) :92-95

[6] Functional repression of cAMP response element in 6-hydroxydopamine-treated neuronal cells [J].

Chalovich, Elisabeth M. ;

Zhu, Jian-Hui ;

Caltagarone, John ;

Bowser, Robert ;

Chu, Charleen T. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (26) :17870-17881

[7] Lithium and valproate differentially regulate brain regional expression of phosphorylated CREB and c-Fos [J].

Chen, B ;

Wang, JF ;

Hill, BC ;

Young, LT .

MOLECULAR BRAIN RESEARCH, 1999, 70 (01) :45-53

[8] The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS [J].

Chen, G ;

Zeng, WZ ;

Yuan, PX ;

Huang, LD ;

Jiang, YM ;

Zhao, ZH ;

Manji, HK .

JOURNAL OF NEUROCHEMISTRY, 1999, 72 (02) :879-882

[9] Ethnobotanical studies on wild edible fruits in southern yunnan: Folk names; nutritional value and usesEthnobotanische studien Über native, eβbare frÜchte im sÜdlichen yunnan: namen der lokalen bevölkerung; wert für die ernÄhrung und ihr nutzen [J].

Chen Jin ;

Su Yin-Chun ;

Chen Gui-Qin ;

Wang Wen-Dun .

Economic Botany, 1999, 53 (1) :2-14

[10] Long term lithium treatment suppresses p53 and Bax expression but increases Bcl-2 expression - A prominent role in neuroprotection against excitotoxicity [J].

Chen, RW ;

Chuang, DM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (10) :6039-6042

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