Insulin-induced lipoatrophy in type I diabetes - A possible tumor necrosis factor-alpha-mediated dedifferentiation of adipocytes

被引:37
作者
AtlanGepner, C
Bongrand, P
Farnarier, C
Xerri, L
Choux, R
Gauthier, JF
Brue, T
Vague, P
Grob, JJ
Vialettes, B
机构
[1] UNIV MARSEILLE,HOP ST MARGUERITE,IMMUNOL LAB,F-13009 MARSEILLE,FRANCE
[2] UNIV MARSEILLE,HOP ST MARGUERITE,ANAT PATHOL LAB,F-13009 MARSEILLE,FRANCE
[3] UNIV MARSEILLE,HOP ST MARGUERITE,SERV DERMATOL,F-13009 MARSEILLE,FRANCE
[4] UNIV MARSEILLE,HOP TIMONE,SERV ENDOCRINOL,MARSEILLE,FRANCE
[5] UNIV MARSEILLE,HOP TIMONE,SERV NUTR & MALADIES METAB,MARSEILLE,FRANCE
[6] HOP ST LOUIS,SERV ENDOCRINOL,PARIS,FRANCE
关键词
D O I
10.2337/diacare.19.11.1283
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE - To lest the hypothesis that tumor necrosis factor (TNF)-alpha may mediate the loss and the dedifferentiation of subcutaneous fat tissue in the insulin induced lipoatrophies of a diabetic patient who presented extensive lesions. RESEARCH DESIGN AND METHODS - An in vitro exploration of cytokine production by peripheral blood mononuclear cells (PBMC) from the reported case was performed and compared with the same explorations of PBMC from three nondiabetic subjects and three diabetic patients without lipoatrophic lesions, A proliferation test and an evaluation of TNF-alpha and interleukin (IL)-6 production from PBMC in presence of insulin were studied. RESULTS - The production of TNF-alpha and IL-6 by the macrophages of the patient in presence of insulin were dramatically increased in comparison with control subjects, This process needed cooperation with other lymphoid cells and was abrogated by dexamethasone. CONCLUSIONS - In our reported case, a local hyperproduction of TNF-alpha from macrophages that was induced by the injected insulin could explain the dedifferentiation of the adipocytes of the subcutaneous tissue and the reversion that was induced by the local injection of dexamethasone.
引用
收藏
页码:1283 / 1285
页数:3
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