A palladium-catalyzed enantioselective alkylative desymmetrization of meso-succinic anhydrides

被引：44

作者：

Bercot, EA ^{[1
]}

Rovis, T ^{[1
]}

机构：

[1] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 33期

关键词：

D O I：

10.1021/ja046528b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Monoalkylation of cyclic anhydrides provides an opportunity to couple a carbon-carbon bond-forming event with the control of backbone stereochemistry. We have developed a palladium-JOSIPHOS catalyst system that desymmetrizes meso-succinic anhydrides using organozinc reagents as nucleophiles, and have found that, in many cases, this reaction proceeds at ambient temperature. Copyright © 2004 American Chemical Society.

引用

页码：10248 / 10249

页数：2

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