Applications of microarrays in the pharmaceutical industry

被引：19

作者：

Crowther, DJ ^{[1
]}

机构：

[1] GlaxoSmithKline, Target Bioinformat, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

CURRENT OPINION IN PHARMACOLOGY | 2002年 / 2卷 / 05期

关键词：

D O I：

10.1016/S1471-4892(02)00207-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Microarrays provide the ability to measure the expression of thousands of genes in parallel. From target discovery through to uses in the clinic, microarrays are having an enormous impact on research in the pharmaceutical industry. In particular, microarrays have applications in genome annotation, they contribute to improving our disease understanding and can be used in the drug development pipeline to improve selection of biological targets and lead compounds.

引用

页码：551 / 554

页数：4

共 36 条

[1] Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling [J].

Alizadeh, AA ;

Eisen, MB ;

Davis, RE ;

Ma, C ;

Lossos, IS ;

Rosenwald, A ;

Boldrick, JG ;

Sabet, H ;

Tran, T ;

Yu, X ;

Powell, JI ;

Yang, LM ;

Marti, GE ;

Moore, T ;

Hudson, J ;

Lu, LS ;

Lewis, DB ;

Tibshirani, R ;

Sherlock, G ;

Chan, WC ;

Greiner, TC ;

Weisenburger, DD ;

Armitage, JO ;

Warnke, R ;

Levy, R ;

Wilson, W ;

Grever, MR ;

Byrd, JC ;

Botstein, D ;

Brown, PO ;

Staudt, LM .

NATURE, 2000, 403 (6769) :503-511

[2] MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia [J].

Armstrong, SA ;

Staunton, JE ;

Silverman, LB ;

Pieters, R ;

de Boer, ML ;

Minden, MD ;

Sallan, SE ;

Lander, ES ;

Golub, TR ;

Korsmeyer, SJ .

NATURE GENETICS, 2002, 30 (01) :41-47

[3] Molecular classification of cutaneous malignant melanoma by gene expression profiling [J].

Bittner, M ;

Meitzer, P ;

Chen, Y ;

Jiang, Y ;

Seftor, E ;

Hendrix, M ;

Radmacher, M ;

Simon, R ;

Yakhini, Z ;

Ben-Dor, A ;

Sampas, N ;

Dougherty, E ;

Wang, E ;

Marincola, F ;

Gooden, C ;

Lueders, J ;

Glatfelter, A ;

Pollock, P ;

Carpten, J ;

Gillanders, E ;

Leja, D ;

Dietrich, K ;

Beaudry, C ;

Berens, M ;

Alberts, D ;

Sondak, V ;

Hayward, N ;

Trent, J .

NATURE, 2000, 406 (6795) :536-540

[4] New developments in microarray technology [J].

Blohm, DH ;

Guiseppi-Elie, A .

CURRENT OPINION IN BIOTECHNOLOGY, 2001, 12 (01) :41-47

[5]

BRAMZA A, 2000, NATURE, V403, P699

[6] Minimum information about a microarray experiment (MIAME) - toward standards for microarray data [J].

Brazma, A ;

Hingamp, P ;

Quackenbush, J ;

Sherlock, G ;

Spellman, P ;

Stoeckert, C ;

Aach, J ;

Ansorge, W ;

Ball, CA ;

Causton, HC ;

Gaasterland, T ;

Glenisson, P ;

Holstege, FCP ;

Kim, IF ;

Markowitz, V ;

Matese, JC ;

Parkinson, H ;

Robinson, A ;

Sarkans, U ;

Schulze-Kremer, S ;

Stewart, J ;

Taylor, R ;

Vilo, J ;

Vingron, M .

NATURE GENETICS, 2001, 29 (04) :365-371

[7] Genomic analysis of metastasis reveals an essential role for RhoC [J].

Clark, EA ;

Golub, TR ;

Lander, ES ;

Hynes, RO .

NATURE, 2000, 406 (6795) :532-535

[8] Large-scale identification of secreted and membrane-associated gene products using DNA microarrays [J].

Diehn, M ;

Eisen, MB ;

Botstein, D ;

Brown, PO .

NATURE GENETICS, 2000, 25 (01) :58-62

[9] Comparing functional genomic datasets: lessons from DNA. microarray analyses of host-pathogen interactions [J].

Diehn, M ;

Relman, DA .

CURRENT OPINION IN MICROBIOLOGY, 2001, 4 (01) :95-101

[10] Cluster analysis and display of genome-wide expression patterns [J].

Eisen, MB ;

Spellman, PT ;

Brown, PO ;

Botstein, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (25) :14863-14868

← 1 2 3 4 →