Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease

被引：185

作者：

Ishizuka, K ^{[1
]}

Kimura, T ^{[1
]}

IgataYi, R ^{[1
]}

Katsuragi, S ^{[1
]}

Takamatsu, J ^{[1
]}

Miyakawa, T ^{[1
]}

机构：

[1] NATL KIKUCHI HOSP,KUMAMOTO,JAPAN

来源：

PSYCHIATRY AND CLINICAL NEUROSCIENCES | 1997年 / 51卷 / 03期

关键词：

Alzheimer's disease; inflammation; microglias; monocyte chemoattractant protein-1; senile plaques;

D O I：

10.1111/j.1440-1819.1997.tb02375.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

It has been shown that human monocytes express monocyte chemoattractant protein-1 (MCP-1), an inflammatry factor, in response to non-fibrillar beta-amyloid protein. Reactive microglia and inflammatory factors were reported to be present in beta-amyloid deposits (senile plaques) in Alzheimer's disease, suggesting the presence of MCP-1 in senile plaques. To address this issue, we examined MCP-1-immunoreactivity in senile plaques using a mouse monoclonal anti-MCP-1 antibody. Monocyte chemoattractant protein-1 was found immunohistochemically in mature senile plaques and reactive microglia but not in immature senile plaques of brain tissues from five patients with Alzheimer's disease. These findings suggest that MCP-1-related inflammatory events induced by reactive microglia contribute to the maturation of senile plaques.

引用

页码：135 / 138

页数：4

共 37 条

[1]

AISEN PS, 1994, AM J PSYCHIAT, V151, P1105

[2] DO NONSTEROIDAL ANTIINFLAMMATORY DRUGS DECREASE THE RISK FOR ALZHEIMERS-DISEASE - THE ROTTERDAM STUDY [J].