Dynamic regulation of transcriptional states by chromatin and transcription factors

被引：345

作者：

Voss, Ty C. ^{[1
]}

Hager, Gordon L. ^{[1
]}

机构：

[1] NCI, Lab Receptor Biol & Gene Express, NIH, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS GENETICS | 2014年 / 15卷 / 02期

关键词：

ESTROGEN-RECEPTOR-ALPHA; EUKARYOTIC GENE-EXPRESSION; SINGLE-MOLECULE TRACKING; GLUCOCORTICOID-RECEPTOR; LIVING CELLS; DNA-BINDING; IN-VIVO; EPIGENETIC SIGNATURES; BIOLOGICAL-SYSTEMS; PROTEIN DYNAMICS;

D O I：

10.1038/nrg3623

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The interaction of regulatory proteins with the complex nucleoprotein structures that are found in mammalian cells involves chromatin reorganization at multiple levels. Mechanisms that support these transitions are complex on many timescales, which range from milliseconds to minutes or hours. In this Review, we discuss emerging concepts regarding the function of regulatory elements in living cells. We also explore the involvement of these dynamic and stochastic processes in the evolution of fluctuating transcriptional activity states that are now commonly reported in eukaryotic systems.

引用

页码：69 / 81

页数：13

共 124 条

[11] Nucleosome retention and the stochastic nature of promoter chromatin remodeling for transcription [J].

Boeger, Hinrich ;

Griesenbeck, Joachim ;

Kornberg, Roger D. .

CELL, 2008, 133 (04) :716-726

[12] A hyper-dynamic equilibrium between promoter-bound and nucleoplasmic dimers controls NF-κB-dependent gene activity [J].

Bosisio, D ;

Marazzi, I ;

Agresti, A ;

Shimizu, N ;

Bianchi, ME ;

Natoli, G .

EMBO JOURNAL, 2006, 25 (04) :798-810

[13] High-resolution mapping and characterization of open chromatin across the genome [J].

Boyle, Alan P. ;

Davis, Sean ;

Shulha, Hennady P. ;

Meltzer, Paul ;

Margulies, Elliott H. ;

Weng, Zhiping ;

Furey, Terrence S. ;

Crawford, Gregory E. .

CELL, 2008, 132 (02) :311-322

[14] Delay-induced stochastic oscillations in gene regulation [J].

Bratsun, D ;

Volfson, D ;

Tsimring, LS ;

Hasty, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (41) :14593-14598

[15] Raster image correlation spectroscopy (RICS) for measuring fast protein dynamics and concentrations with a commercial laser scanning confocal microscope [J].

Brown, C. M. ;

Dalal, R. B. ;

Hebert, B. ;

Digman, M. A. ;

Horwitz, A. R. ;

Gratton, E. .

JOURNAL OF MICROSCOPY-OXFORD, 2008, 229 (01) :78-91

[16] Revisiting the Central Dogma One Molecule at a Time [J].

Bustamante, Carlos ;

Cheng, Wei ;

Meija, Yara X. .

CELL, 2011, 144 (04) :480-497

[17] Frequency-modulated nuclear localization bursts coordinate gene regulation [J].

Cai, Long ;

Dalal, Chiraj K. ;

Elowitz, Michael B. .

NATURE, 2008, 455 (7212) :485-U16

[18] Chromatin remodeling: insights and intrigue from single-molecule studies [J].

Cairns, Bradley R. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2007, 14 (11) :989-996

[19] Transcriptional pulsing of a developmental gene [J].

Chubb, JR ;

Trcek, T ;

Shenoy, SM ;

Singer, RH .

CURRENT BIOLOGY, 2006, 16 (10) :1018-1025

[20] Specific interactions of the wing domains of FOXA1 transcription factor with DNA [J].

Cirillo, Lisa A. ;

Zaret, Kenneth S. .

JOURNAL OF MOLECULAR BIOLOGY, 2007, 366 (03) :720-724

← 1 2 3 4 5 6 7 8 9 10 →