Macrophage apoptosis in host immunity to mycobacterial infections

被引：33

作者：

Fairbairn, IP ^{[1
]}

机构：

[1] Univ Edinburgh, Edinburgh, Midlothian, Scotland

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2004年 / 32卷

关键词：

apoptosis; granuloma; macrophage; mycobacterium; tuberculosis; virulence;

D O I：

10.1042/BST0320496

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Macrophage apoptosis occurs within the granuloma, which is essential for successful immunity to tuberculosis. In vitro macrophage apoptosis is associated with the killing of intracellular Mycobacterium tuberculosis. A greater understanding of these observations will lead to new immunotherapies and improved vaccine design. The relevant apoptotic stimuli, the anti-mycobacterial mechanisms that they stimulate and their physiological relevance are reviewed in this paper.

引用

收藏

页码：496 / 498

页数：3

相关论文

共 34 条

[1] The apoptotic signaling pathway activated by Toll-like receptor-2 [J].

Aliprantis, AO ;

Yang, RB ;

Weiss, DS ;

Godowski, P ;

Zychlinsky, A .

EMBO JOURNAL, 2000, 19 (13) :3325-3336

[2] Inherited interleukin 12 deficiency in a child with bacille Calmette-Guerin and Salmonella enteritidis disseminated infection [J].

Altare, F ;

Lammas, D ;

Revy, P ;

Jouanguy, E ;

Döffinger, R ;

Lamhamedi, S ;

Drysdale, P ;

Scheel-Toellner, D ;

Girdlestone, J ;

Darbyshire, P ;

Wadhwa, M ;

Dockrell, H ;

Salmon, M ;

Fischer, A ;

Durandy, A ;

Casanova, JL ;

Kumararatne, DS .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (12) :2035-2040

[3] Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors [J].

Brightbill, HD ;

Libraty, DH ;

Krutzik, SR ;

Yang, RB ;

Belisle, JT ;

Bleharski, JR ;

Maitland, M ;

Norgard, MV ;

Plevy, SE ;

Smale, ST ;

Brennan, PJ ;

Bloom, BR ;

Godowski, PJ ;

Modlin, RL .

SCIENCE, 1999, 285 (5428) :732-736

[4] KILLING OF VIRULENT MYCOBACTERIUM-TUBERCULOSIS BY REACTIVE NITROGEN INTERMEDIATES PRODUCED BY ACTIVATED MURINE MACROPHAGES [J].

CHAN, J ;

XING, Y ;

MAGLIOZZO, RS ;

BLOOM, BR .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 175 (04) :1111-1122

[5] CELL-DEATH IN GRANULOMATA - THE ROLE OF APOPTOSIS [J].

CREE, IA ;

NURBHAI, S ;

MILNE, G ;

BECK, JS .

JOURNAL OF CLINICAL PATHOLOGY, 1987, 40 (11) :1314-1319

[6] ATP-mediated killing of intracellular mycobacteria by macrophages is a P2X7-dependent process inducing bacterial death by phagosome-lysosome fusion [J].

Fairbairn, IP ;

Stober, CB ;

Kumararatne, DS ;

Lammas, DA .

JOURNAL OF IMMUNOLOGY, 2001, 167 (06) :3300-3307

[7]

Fayyazi A, 2000, J PATHOL, V191, P417, DOI 10.1002/1096-9896(2000)9999:9999&lt

[8]

::AID-PATH664&gt

[9]

3.0.CO

[10]

2-R

← 1 2 3 4 →