Programmed cell death in trypanosomatids:: a way to maximize their biological fitness?

被引：61

作者：

Nguewa, PA

Fuertes, MA

Valladares, B

Alonso, C

Pérez, JM

机构：

[1] Univ La Laguna, Fac Farm, Dept Parasitol, San Cristobal la Laguna 38071, Tenerife, Spain

[2] Univ Autonoma Madrid, Fac Ciencias, CSIC, Ctr Biol Mol Severo Ochoa, E-28049 Madrid, Spain

[3] Univ Autonoma Madrid, Fac Ciencias, Dept Quim Inorgan, E-28049 Madrid, Spain

来源：

TRENDS IN PARASITOLOGY | 2004年 / 20卷 / 08期

关键词：

D O I：

10.1016/j.pt.2004.05.006

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Programmed cell death (PCD) is a biochemical process that plays an essential role in the development of multicellular organisms. However, accumulating evidence indicates that PCD is also present in single-celled eukaryotes. Thus, trypanosomatids might be endowed with a PCD mechanism that is derived from ancestral death machinery. PCD in trypanosomatids could be a process without a defined function, inherited through eukaryotic cell evolution, which might be triggered in response to diverse stimuli and stress conditions. However, recent observations suggest that PCD might be used by trypanosomatids to maximize their biological fitness. Therefore, PCD could represent a potential pharmacological target for protozoan control.

引用

页码：375 / 380

页数：6

共 67 条

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