Roles for Vitamin K Beyond Coagulation

被引：164

作者：

Booth, Sarah L. ^{[1
]}

机构：

[1] Tufts Univ, Vitamin K Lab, Jean Mayer USDA, Human Nutr Res Ctr, Boston, MA 02111 USA

来源：

ANNUAL REVIEW OF NUTRITION | 2009年 / 29卷

关键词：

vitamin K; phylloquinone; menaquinones; osteoporosis; calcification; BONE-MINERAL DENSITY; MATRIX GLA PROTEIN; GAMMA-CARBOXYGLUTAMIC ACID; CORONARY-HEART-DISEASE; SERUM UNDERCARBOXYLATED OSTEOCALCIN; RANDOMIZED CONTROLLED-TRIAL; YOUNG MALE-VOLUNTEERS; POSTMENOPAUSAL WOMEN; HIP FRACTURE; PHYLLOQUINONE VITAMIN-K-1;

D O I：

10.1146/annurev-nutr-080508-141217

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Recent interest in vitamin K has been motivated by evidence of physiological roles beyond that of coagulation. Vitamin K and vitamin K-dependent (VKD) proteins may be involved in regulation of calcification, energy metabolism, and inflammation. However, the evidence for many of these proposed roles in the maintenance of health is equivocal. There is also an emerging viewpoint that the biochemical function of vitamin K may extend beyond that of a cofactor for the VKD carboxylation of glutamyl residues (Glus) to carboxylated Glus in VKD proteins.

引用

页码：89 / 110

页数：22

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