The CD154/CD40 interaction required for retrovirus-induced murine immunodeficiency syndrome is not mediated by upregulation of the CD80/CD86 costimulatory molecules

被引：13

作者：

Green, KA

Cook, WJ

Sharpe, AH

Green, WR

机构：

[1] Dartmouth Coll Sch Med, Dept Microbiol & Immunol, Lebanon, NH 03756 USA

[2] Dartmouth Coll Sch Med, Norris Cotton Canc Ctr, Lebanon, NH 03756 USA

[3] Brigham & Womens Hosp, Boston, MA 02115 USA

来源：

JOURNAL OF VIROLOGY | 2002年 / 76卷 / 24期

关键词：

D O I：

10.1128/JVI.76.24.13106-13110.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

C57BL/6 (B6) mice infected with LP-BM5 retroviruses develop disease, including an immunodeficiency similar to AIDS. This disease, murine AIDS (MAIDS), is inhibited by in vivo anti-CD154 monoclonal antibody treatment. The similar levels of insusceptibility of CD40(-/-) and CD154(-/-) B6 mice indicate that CD154/CD40 molecular interactions are required for MAIDS. CD4(+) T and B cells, respectively, provide the CD154 and CD40 expression needed for MAIDS induction. Here, the required CD154/CD40 interaction is shown to be independent of CD80 and CD86 expression: CD80/CD86(-/-) B6 mice develop MAIDS after LP-BM5 infection.

引用

收藏

页码：13106 / 13110

页数：5

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