Evaluation of serum lipids and carotid artery intima media thickness in epileptic children treated with valproic acid

被引：37

作者：

Erdemir, Aydin ^{[1
]}

Cullu, Nesat ^{[2
]}

Yis, Uluc ^{[1
]}

Demircioglu, Fatih ^{[1
]}

Kir, Mustafa ^{[3
]}

Cakmakci, Handan ^{[2
]}

Unal, Nurettin ^{[3
]}

Dirik, Eray ^{[1
]}

机构：

[1] Dokuz Eylul Univ, Sch Med, Dept Pediat, Div Pediat Neurol, TR-35340 Izmir, Turkey

[2] Dokuz Eylul Univ, Sch Med, Dept Radiol, TR-35340 Izmir, Turkey

[3] Dokuz Eylul Univ, Sch Med, Dept Pediat, Div Pediat Cardiol, TR-35340 Izmir, Turkey

来源：

BRAIN & DEVELOPMENT | 2009年 / 31卷 / 10期

关键词：

Child; Epilepsy; Intima media thickness; Valproic acid; DENSITY-LIPOPROTEIN CHOLESTEROL; RECEIVING ANTIEPILEPTIC DRUGS; TERM ANTICONVULSIVE TREATMENT; PLASMA; THERAPY; CARBAMAZEPINE; DISEASE;

D O I：

10.1016/j.braindev.2008.11.001

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

The aim of this study is to evaluate the carotid artery intima media thickness and serum lipids in pediatric patients with epilepsy treated with valproic acid. The study included 44 pediatric epileptic and 40 healthy children. Intima media thickness of left common carotid artery and fasting lipid profile (total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol) were assessed. Although we did not observe any differences regarding serum lipid profiles, intima media thickness of common carotid artery was significantly higher in epileptic patients treated with valproic acid. We suggest that this increase in intima media thickness of common carotid artery may be due to epilepsy and/or valproic acid treatment. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：713 / 716

页数：4

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