Dose and duration of fenfluramine-phentermine therapy impacts the risk of significant valvular heart disease

被引：18

作者：

Lepor, NE

Gross, SB

Daley, WL

Samuels, BA

Rizzo, MJ

Luko, SP

Hickey, A

Buchbinder, NA

Naqvi, TZ

机构：

[1] Heart Ctr Los Angeles, Los Angeles, CA 90048 USA

[2] Harvard Univ, Sch Med, Brigham & Womens Hosp, Vet Adm Med Ctr W Roxbury, Boston, MA USA

[3] Cedars Sinai Med Ctr, Div Cardiol, Los Angeles, CA 90048 USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2000年 / 86卷 / 01期

关键词：

D O I：

10.1016/S0002-9149(00)00840-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Among a cohort of patients exposed to the anorexic combination fenfluramine-phentermine, a 30.6% rate of significant valvular regurgitation was found, predominantly affecting the aortic valve. Both the dose of combination therapy and longer duration of use were significant predictors of valve regurgitation.

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页码：107 / +

页数：5

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