The structural biology of type IV secretion systems

被引：295

作者：

Fronzes, Remi ^{[1
]}

Christie, Peter J. ^{[2
]}

Waksman, Gabriel ^{[1
]}

机构：

[1] Inst Struct & Mol Biol, London WC1E 7HX, England

[2] Univ Texas Houston, Sch Med, Dept Microbiol & Mol Genet, Houston, TX 77030 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2009年 / 7卷 / 10期

基金：

美国国家卫生研究院; 英国惠康基金;

关键词：

T-DNA TRANSFER; AGROBACTERIUM-TUMEFACIENS VIRB7; COMPLEX TRANSPORT APPARATUS; PERTUSSIS TOXIN SECRETION; GRAM-NEGATIVE BACTERIA; ESSENTIAL VIRULENCE PROTEIN; CAG PATHOGENICITY ISLAND; TRAG-LIKE PROTEINS; HELICOBACTER-PYLORI; ESCHERICHIA-COLI;

D O I：

10.1038/nrmicro2218

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Type IV secretion systems (T4SSs) are versatile secretion systems that are found in both Gram-negative and Gram-positive bacteria and secrete a wide range of substrates, from single proteins to protein-protein and protein-DNA complexes. They usually consist of 12 components that are organized into ATP-powered, double-membrane-spanning complexes. The structures of single soluble components or domains have been solved, but an understanding of how these structures come together has only recently begun to emerge. This Review focuses on the structural advances that have been made over the past 10 years and how the corresponding structural insights have helped to elucidate many of the details of the mechanism of type IV secretion.

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收藏

页码：703 / 714

页数：12

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