Model of the most abundant DNA interstrand cross-link of Transplatin:: X-ray structures of two modifications and H bonding behavior in the solid state and in solution of trans-[Pt(NH3)2(1-MeC-N3)(9-EtGH-N7)](ClO4)2•nH2O (1-MeC=1-methylcytosine; 9-EtGH=9-ethylguanine)

被引：26

作者：

Erxleben, A

Metzger, S

Britten, JF

Lock, CJL

Albinati, A

Lippert, B

机构：

[1] Univ Dortmund, Dept Chem, D-44221 Dortmund, Germany

[2] McMaster Univ, Dept Chem, Labs Inorgan Med, Hamilton, ON L8S 4M1, Canada

[3] Univ Milan, Ist Chim Farmaceut, I-20131 Milan, Italy

来源：

INORGANICA CHIMICA ACTA | 2002年 / 339卷

关键词：

transplatin; mixed cytosine; guanine complexes; H bonding; X-ray crystallography;

D O I：

10.1016/S0020-1693(02)00955-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The preparation, the crystal structure determination of two modifications, and the solution behavior of the mixed nucleobase complex trans-[Pt(NH3)(2)(1-MeC-N3)(9-EtGH-N7)](ClO4)(2).n H2O (n = 1.4 (2a) and 0 (2b)) with 1-MeC = 1-methylcytosine and 9-EtGH = 9-ethylguanine are reported. The compound is a model for the most abundant interstrand cross-link of trans-Pt(NH3)(2)Cl-2 (Transplatin) with double-stranded DNA. Characteristic features of this compound are the near-coplanarity of the two nucleobases and the intracomplex H bond between the exocyclic groups N(4)H-2 of 1-MeC and O(6) of 9-EtGH. Geometrical parameters responsible for the length of this H bond are studied. The compound can be considered a metal-modified Hoogsteen pair of cytosine and guanine. Its potential relevance to platinated DNA triplexes is also briefly discussed. (C) 2002 Published by Elsevier Science B.V.

引用

页码：461 / 469

页数：9

共 61 条

[1] Monofunctional trans-PtII(NH3)2 modification of pyrimidine-rich deoxyoligonucleotides:: direct platination and use of a protective group [J].