An Orwellian discourse on the meaning and measurement of noninferiority

被引：7

作者：

Diamond, George A. ^{[1
]}

Kaul, Sanjay

机构：

[1] Univ Calif Los Angeles, Cedars Sinai Med Ctr, Div Cardiol, Los Angeles, CA 90024 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90024 USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2007年 / 99卷 / 02期

关键词：

D O I：

10.1016/j.amjcard.2006.07.090

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The customary interpretation of active-controlled noninferiority trials is founded on a number of unverifiable assumptions. These assumptions can be circumvented, and the semantic and statistic interpretation of the trials placed on a more rational foundation, if treatment comparisons are analyzed from a Bayesian perspective. In conclusion, the resultant probabilistic measures thereby render the meaning of noninferiority more transparent and clinically relevant. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：284 / 287

页数：4

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