Innovation - Prenatal diagnosis: progress through plasma nucleic acids

被引：142

作者：

Lo, Y. M. Dennis

Chiu, Rossa W. K.

机构：

[1] Chinese Univ Hong Kong, Prince Wales Hosp, Li Ka Shing Inst Hlth Sci, Shatin, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Chem Pathol, Shatin, Hong Kong, Peoples R China

来源：

NATURE REVIEWS GENETICS | 2007年 / 8卷 / 01期

关键词：

D O I：

10.1038/nrg1982

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Over the past 40 years, much effort has been spent on developing noninvasive prenatal diagnostic methods. Since 1997, the progress of this field has been accelerated by the unexpected finding of extracellular fetal nucleic acids in maternal plasma. These developments have been translated into many novel genetic, epigenetic and gene-expression markers, and are expected to have a fundamental impact on the future practice of prenatal diagnosis.

引用

页码：71 / 77

页数：7

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