A convenient synthesis of amides and nitriles with a branched and conjugated dienyne structure

被引：11

作者：

Fiandanese, V ^{[1
]}

Babudri, F ^{[1
]}

Marchese, G ^{[1
]}

Punzi, A ^{[1
]}

机构：

[1] Univ Bari, Dipartimento Chim, CNR, ICCOM, I-70126 Bari, Italy

来源：

TETRAHEDRON | 2002年 / 58卷 / 47期

关键词：

silicons and compounds; dienynes; amides; nitriles;

D O I：

10.1016/S0040-4020(02)01282-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and stereoselective synthetic approach to a variety of amides and nitriles with a branched and conjugated dienyne structure has been developed, starting from a readily available mono-silylated unsaturated amide and nitrile with an enyne structure. A nucleophilic hydrohalogenation of the triple bond of the enynes with NaI afforded a Z,E-iododienamide and a Z,E-iododienenitrile that, subjected to palladium-catalyzed cross-coupling reactions with a variety of terminal alkynes, led directly to the title compounds. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：9547 / 9552

页数：6

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