FLT3 internal tandem duplication in childhood acute myeloid leukaemia: association with hyperleucocytosis in acute promyelocytic leukaemia

被引：42

作者：

Arrigoni, P

Beretta, C

Silvestri, D

Rossi, V

Rizzari, C

Valsecchi, MG

Cazzaniga, G

Biondi, A

机构：

[1] Univ Milano Bicocca, Pediat Clin, Ctr Ric M Tettamanti, Milan, Italy

[2] Osped San Gerardo, Dipartimento Med Clin Prevenz & Biotecnol Sanitar, Monza, Italy

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2003年 / 120卷 / 01期

关键词：

FLT3/ITD; childhood AML; childhood APL; M3; variant;

D O I：

10.1046/j.1365-2141.2003.04032.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We evaluated the incidence of FLT3/internal tandem duplication (ITD) mutation in childhood acute myeloid leukaemia (AML) diagnosed over 15 years. FLT3/ITD was found in 10 of 45 (22.2%) non-acute promyelocytic leukaemia (non-APL) patients. The 5-year event-free survival of non-APL patients was higher in FLT3/ITD-negative versus -positive patients (48.9%, SE 8.9, vs 20.0%, SE 16.1, P = 0.03). In childhood APL, FLT3/ITD incidence was higher than in non-APL, although not statistically significant (10 out of 29 patients, 34.5%, P = 0.29). In APL patients, FLT3/ITD was strongly correlated to a higher white blood cell count at diagnosis and the M3 French-American-British subtype.

引用

页码：89 / 92

页数：4

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