Partial Occlusion of the Descending Aorta Increases Cerebral Blood Flow in a Nonstroke Porcine Model

被引：32

作者：

Hammer, Maxim ^{[3
]}

Jovin, Tudor ^{[3
]}

Wahr, Joyce A. ^{[2
]}

Heiss, Wolf-Dieter ^{[1
]}

机构：

[1] Max Planck Inst Neurol Res, DE-50931 Cologne, Germany

[2] CoAxia Inc, Maple Grove, MN USA

[3] Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15260 USA

来源：

CEREBROVASCULAR DISEASES | 2009年 / 28卷 / 04期

关键词：

Cerebral blood flow; Cerebral perfusion augmentation; Partial aortic occlusion; ACUTE ISCHEMIC-STROKE; OBSTRUCTION; PERFUSION;

D O I：

10.1159/000235628

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: We studied the effect of partial aortic occlusion on cerebral perfusion and cardiac performance using the intra-aortic NeuroFlo (TM) catheter. Methods: Adult pigs were instrumented to determine cardiac parameters; unique isotope-labeled microspheres were used to determine cerebral blood flow (CBF) before, during and after sequential partial aortic occlusion. Results: Six pigs were studied; there was no relevant change in cardiac output, and the desired pressure drop of 10-15 mm Hg across the balloons was achieved. CBF increased significantly with inflation of the suprarenal balloon and remained elevated 90 min after deflation. Conclusions: Partial aortic occlusion with the NeuroFlo catheter significantly increased cerebral perfusion without adversely affecting cardiac performance. Copyright (C) 2009 S. Karger AG, Basel

引用

页码：406 / 410

页数：5

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