Alginate-Based Hydrogels and Tubes, as Biological Macromolecule-Based Platforms for Peripheral Nerve Tissue Engineering: A Review

被引：52

作者：

Abdelbasset, Walid Kamal ^{[1
,2
]}

Jasim, Saade Abdalkareem ^{[3
]}

Sharma, Satish Kumar ^{[4
]}

Margiana, Ria ^{[5
,6
,7
]}

Bokov, Dmitry Olegovich ^{[8
,9
]}

Obaid, Maithm A. ^{[10
]}

Hussein, Baydaa Abed ^{[11
]}

Lafta, Holya A. ^{[12
]}

Jasim, Sara Firas ^{[13
]}

Mustafa, Yasser Fakri ^{[13
]}

机构：

[1] Prince Sattam Bin Abdulaziz Univ, Coll Appl Med Sci, Dept Hlth & Rehabil Sci, POB 173, Al Kharj 11942, Saudi Arabia

[2] Cairo Univ, Kasr Al Aini Hosp, Dept Phys Therapy, Giza 12613, Egypt

[3] Al Maarif Univ Coll, Med Lab Tech Dept, Al Anbar Ramadi, Iraq

[4] Glocal Univ, Glocal Sch Pharm, Pharmacol Dept, Saharanpur, India

[5] Univ Indonesia, Fac Med, Dept Anat, Jakarta, Indonesia

[6] Univ Indonesia, Fac Med, Masters Programme Biomed Sci, Jakarta, Indonesia

[7] Dr Soetomo Gen Acad Hosp, Surabaya, Indonesia

[8] Sechenov First Moscow State Med Univ, Inst Pharm, 8 Trubetskaya St,Bldg 2, Moscow 119991, Russia

[9] Fed Res Ctr Nutr Biotechnol & Food Safety, Lab Food Chem, 2-14 Ustyinsky Pr, Moscow 109240, Russia

[10] Natl Univ Sci & Technol, Coll Pharm, Thi Qar, Iraq

[11] Al Manara Coll Med Sci, Misan, Iraq

[12] Al Nisour Univ Coll, Baghdad, Iraq

[13] Univ Mosul, Coll Pharm, Dept Pharmaceut Chem, Mosul 41001, Iraq

来源：

ANNALS OF BIOMEDICAL ENGINEERING | 2022年 / 50卷 / 06期

关键词：

Alginate; Peripheral nervous system; Neural guidance channels; Hydrogel; Tissue regeneration; STEM-CELLS; IN-VITRO; SODIUM ALGINATE; 3D CULTURE; REGENERATION; SCAFFOLDS; CONDUITS; COMPOSITES; REPAIR; MICROPARTICLES;

D O I：

10.1007/s10439-022-02955-8

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Unlike the central nervous system, the peripheral nervous system (PNS) has an inherent capacity to regenerate following injury. However, in the case of large nerve defects where end-to-end cooptation of two nerve stumps is not tension-free, autologous nerve grafting is often utilized to bridge the nerve gaps. To address the challenges associated with autologous nerve grafting, neural guidance channels (NGCs) have been successfully translated into clinic. Furthermore, hydrogel-based drug delivery systems have been extensively studied for the repair of PNS injuries. There are numerous biomaterial options for the production of NGCs and hydrogels. Among different candidates, alginate has shown promising results in PNS tissue engineering. Alginate is a naturally occurring polysaccharide which is biocompatible, non-toxic, non-immunogenic, and possesses modifiable properties. In the current review, applications, challenges, and future perspectives of alginate-based NGCs and hydrogels in the repair of PNS injuries will be discussed. [GRAPHICS] .

引用

页码：628 / 653

页数：26

共 95 条

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Polymeric Scaffolds in Neural Tissue Engineering: A Review [J].