Alphavirus expression vectors and their use as recombinant vaccines: A minireview

被引：48

作者：

Tubulekas, I ^{[1
]}

Berglund, P ^{[1
]}

Fleeton, M ^{[1
]}

Liljestrom, P ^{[1
]}

机构：

[1] KAROLINSKA INST,DEPT BIOSCI,S-14157 HUDDINGE,SWEDEN

来源：

GENE | 1997年 / 190卷 / 01期

关键词：

Semliki Forest virus; self-replicating RNA; transfection; helper vector; nucleic acid vaccine; togaviruses;

D O I：

10.1016/S0378-1119(96)00679-8

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Alphavirus vectors have become widely used in basic research to study the structure and function of proteins and for protein production purposes. Development of a variety of vectors has made it possible to deliver foreign sequences as naked RNA or DNA, or as suicide virus particles produced using helper vector strategies. Preliminary reports also suggest that these vectors may be useful for in vivo applications where transient, high-level protein expression is desired, such as recombinant vaccines. The initial studies have already shown that alphavirus vaccines can induce strong humoral and cellular immune responses with good immunological memory and protective effects.

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页码：191 / 195

页数：5

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