Diffuse thalamic degeneration in fatal familial insomnia. A morphometric study

被引：53

作者：

Macchi, G

Rossi, G

Abbamondi, AL

Giaccone, G

Mancia, D

Tagliavini, F

Bugiani, O

机构：

[1] IST NEUROL CARLO BESTA,I-20133 MILAN,ITALY

[2] UNIV SACRED HEART,I-00168 ROME,ITALY

[3] UNIV SIENA,NEUROL CLIN,I-53100 SIENA,ITALY

[4] UNIV PARMA,NEUROL CLIN,I-43100 PARMA,ITALY

来源：

BRAIN RESEARCH | 1997年 / 771卷 / 01期

关键词：

thalamus; insomnia; prion disease;

D O I：

10.1016/S0006-8993(97)00902-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

A morphometric investigation disclosed most thalamic nuclei severely degenerated in two patients with fatal familial insomnia. Associative and motor nuclei lost 90% neurons, and limbic-paralimbic, intralaminar and reticular nuclei lost 60% These findings point to the disorganization of most thalamic circuits as a condition necessary for the sleep-wake rhythm being affected. (C) 1997 Elsevier Science B.V.

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收藏

页码：154 / 158

页数：5

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