HIV entry inhibition by the envelope 2 glycoprotein of GB virus C

被引：47

作者：

Jung, Susan ^{[1
]}

Eichenmueller, Melanie

Donhauser, Norbert

Neipel, Frank

Engel, Alfred M.

Hess, Georg

Fleckenstein, Bernhard

Reil, Heide

机构：

[1] Univ Erlangen Nurnberg, Univ Hosp, Inst Clin & Mol Virol, Erlangen, Germany

[2] Roche Diagnost GmbH, Mannheim, Germany

来源：

AIDS | 2007年 / 21卷 / 05期

关键词：

D O I：

10.1097/QAD.0b013e32803277c7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Epidemiological studies have revealed an association between GB virus C (GBV-C) long-term viraemia and ameliorated HIV disease progression. We have provided evidence that a single protein of GBV-C, the glycoprotein E2, interferes with early HIV replication steps of both X4- and R5-tropic HIV strains. Preincubation with anti-E2 antibody specifically abrogates the inhibitory effect. Results were confirmed by the in-vitro expression of GBV-C E1/E2 encoding RNA.

引用

页码：645 / 647

页数：3

共 9 条

[1] GB virus C: Insights into co-infection [J].

Berzsenyi, MD ;

Bowden, DS ;

Roberts, SK .

JOURNAL OF CLINICAL VIROLOGY, 2005, 33 (04) :257-266

[2] Cell surface heparan sulfate is a receptor for human herpesvirus 8 and interacts with envelope glycoprotein K8.1 [J].

Birkmann, A ;

Mahr, K ;

Ensser, A ;

Yaguboglu, S ;

Titgemeyer, F ;

Fleckenstein, B ;

Neipel, F .

JOURNAL OF VIROLOGY, 2001, 75 (23) :11583-11593

[3] GB virus C replicates in primary T and B lymphocytes [J].

George, SL ;

Varmaz, D ;

Stapleton, JT .

JOURNAL OF INFECTIOUS DISEASES, 2006, 193 (03) :451-454

[4] Inhibition of HIV strains by GB virus C in cell culture can be mediated by CD4 and CD8 T-lymphocyte derived soluble factors [J].

Jung, S ;

Knauer, O ;

Donhauser, N ;

Eichenmüller, M ;

Helm, M ;

Fleckenstein, B ;

Reil, H .

AIDS, 2005, 19 (12) :1267-1272

[5]

Kaiser T, 2005, AIDS REV, V7, P3

[6] Characterization of an immunodominant antigenic site on GB virus C glycoprotein E2 that is involved in cell binding [J].

McLinden, James H. ;

Kaufman, Thomas M. ;

Xiang, Jinhua ;

Chang, Qing ;

Klinzman, Donna ;

Engel, Alfred M. ;

Hess, Georg ;

Schmidt, Urban ;

Houghton, Michael ;

Stapleton, Jack T. .

JOURNAL OF VIROLOGY, 2006, 80 (24) :12131-12140

[7] Regulation of CC chemokine receptor 5 in hepatitis G virus infection [J].

Nattermann, J ;

Nischalke, HD ;

Kupfer, B ;

Rockstroh, J ;

Hess, L ;

Sauerbruch, T ;

Spengler, U .

AIDS, 2003, 17 (10) :1457-1462

[8]

Tacke M, 1997, HEPATOLOGY, V26, P1626, DOI 10.1002/hep.510260635

[9] Inhibition of HIV-1 veplication by GB virus C infection through increases in RANTES, MIP-1α, MIP-1β, and SDF-1 [J].

Xiang, JH ;

George, SL ;

Wünschmann, S ;

Chang, Q ;

Klinzman, D ;

Stapleton, JT .

LANCET, 2004, 363 (9426) :2040-2046

← 1 →