Mechanisms of vascular calcification

被引：87

作者：

El-Abbadi, Mohga ^{[1
]}

Giachelli, Cecilia M. ^{[1
]}

机构：

[1] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

来源：

ADVANCES IN CHRONIC KIDNEY DISEASE | 2007年 / 14卷 / 01期

关键词：

vascular calcification; phosphate; calcium; smooth muscle; chronic kidney disease;

D O I：

10.1053/j.ackd.2006.10.007

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Vascular calcification is highly prevalent and correlated with high rates of cardiovascular mortality in chronic kidney disease patients. Recent evidence suggests that mineral, hormonal, and metabolic imbalances that promote phenotype change in vascular cells as well as deficiencies in specific mineralization inhibitory pathways may be important contributory factors for vascular calcification in these patients. This article reviews current mechanisms proposed for the regulation of vascular calcification and data supporting their potential contribution to this process in chronic kidney disease. (c) 2007 by the National Kidney Foundation, Inc.

引用

页码：54 / 66

页数：13

共 187 条

[1] N-3 fatty acids inhibit vascular calcification via the p38-mitogen-activated protein kinase and peroxisome proliferator-activated receptor-γ pathways [J].

Abedin, M ;

Lim, J ;

Tang, TB ;

Park, D ;

Demer, LL ;

Tintut, Y .

CIRCULATION RESEARCH, 2006, 98 (06) :727-729

[2] Calciphylaxis is associated with hyperphosphatemia and increased osteopontin expression by vascular smooth muscle cells [J].

Ahmed, S ;

O'Neill, KD ;

Hood, AF ;

Evan, AP ;

Moe, SM .

AMERICAN JOURNAL OF KIDNEY DISEASES, 2001, 37 (06) :1267-1276

[3]

[Anonymous], 2000, The Kidney

[4] Two year comparison of sevelamer and calcium carbonate effects on cardiovascular calcification and bone density [J].

Asmus, HG ;

Braun, J ;

Krause, R ;

Brunkhorst, R ;

Holzer, H ;

Schulz, W ;

Neumayer, HH ;

Raggi, P ;

Bommer, J .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2005, 20 (08) :1653-1661

[5] EFFECT OF SOME INHIBITORS ON NUCLEATION AND CRYSTAL GROWTH OF APATITE [J].

BACHRA, BN ;

FISCHER, HRA .

CALCIFIED TISSUE RESEARCH, 1969, 3 (04) :348-&

[6]

Baker S B, 2002, Crit Care Resusc, V4, P301

[7] An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia [J].

Benet-Pagès, A ;

Orlik, P ;

Strom, TM ;

Lorenz-Depiereux, B .

HUMAN MOLECULAR GENETICS, 2005, 14 (03) :385-390

[8] Prevalence and correlates of coronary calcification in black and white young adults - The coronary artery risk development in young adults - (CARDIA) study [J].

Bild, DE ;

Folsom, AR ;

Lowe, LP ;

Sidney, S ;

Kiefe, C ;

Westfall, AO ;

Zheng, ZJ ;

Rumberger, J .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2001, 21 (05) :852-857

[9] Regulation of osteogenesis by fetuin [J].

Binkert, C ;

Demetriou, M ;

Sukhu, B ;

Szweras, M ;

Tenenbaum, HC ;

Dennis, JW .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (40) :28514-28520

[10] Mineral metabolism, mortality, and morbidity in maintenance hemodialysis [J].

Block, GA ;

Klassen, PS ;

Lazarus, JM ;

Ofsthun, N ;

Lowrie, EG ;

Chertow, GM .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2004, 15 (08) :2208-2218

← 1 2 3 4 5 6 7 8 9 10 →