Colony formation of C57BL/6J mice in visible burrow system: Identification of eusocial behaviors in a background strain for genetic animal models of autism

被引:70
作者
Arakawa, Hiroyuki
Blanchard, D. Caroline
Blanchard, Robert J.
机构
[1] Univ Hawaii Manoa, Pacific Biosci Res Ctr, Honolulu, HI 96822 USA
[2] Univ Hawaii Manoa, Div Neurosci, John A Burns Sch Med, Honolulu, HI 96822 USA
[3] Univ Hawaii Manoa, Dept Psychol, Honolulu, HI 96822 USA
基金
日本学术振兴会;
关键词
autism model; social behavior; huddling; colony formation; VBS; C57BL/6J mice; INBRED MOUSE STRAINS; HOUSE MICE; MUS-MUSCULUS; SOCIAL INTERACTIONS; BODY-TEMPERATURE; RECOGNITION; PHENOTYPES; BRAIN; NEUROBIOLOGY; SOCIABILITY;
D O I
10.1016/j.bbr.2006.07.027
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
010107 [宗教学]; 030301 [社会学]; 070906 [古生物学及地层学(含古人类学)];
摘要
Deficits in social interaction are primary characteristics of autism, which has strong genetic components. Genetically manipulated mouse models may provide a useful research tool to advance the investigation of genes associated with autism. To identify these genes using mouse models, behavioral assays for social relationships in the background strains must be developed. The present study examined colony formation in groups of one male and three female mice (Experiment 1) and, groups of three male mice (Experiment 2) of the C57BL/6J strain in a semi-natural visible burrow system. For adult mixed-sex colonies, 4-h observations during both the dark and light cycles for 15 days demonstrated day-dependent increases in huddling together in the chamber accompanied by decreased frequencies of active social behaviors. Sequential analyses of social interactions indicated that approaches to the back of the approached animal typically elicited flight, while approaches to the front of the approached animal failed to do so. This was seen for female to female, and for female to male approaches, as well as male to female approaches, strongly counterindicating a view that rear approach/flight specifically reflects female responsivirity to unwanted male sexual approach. For adult male colonies, similar protocols found that these social behaviors were similar to those of adult mixed-sex colonies. These findings suggest two potentially useful measures of eusocial behavior in mice, of possible value for genetic mouse models of autism; that is, huddling together and approaches to the front but not the back. of conspecifics. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码:27 / 39
页数:13
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