Synthesis and in vitro cytotoxicity of aminocoumarin platinum(II) complexes

被引：39

作者：

Kokotos, G ^{[1
]}

Theodorou, V ^{[1
]}

Tzougraki, C ^{[1
]}

Deforce, DLD ^{[1
]}

VandenEeckhout, EG ^{[1
]}

机构：

[1] STATE UNIV GHENT,LAB PHARMACEUT BIOTECHNOL,B-9000 GHENT,BELGIUM

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(97)00384-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A number of cis-dichloro[bis(aminocoumarin)]platinum complexes have been synthesized and evaluated for their in vitro cytotoxicity against Caco-2T cells. The complex with 7-amino-4-trifluoromethylcoumarin as ligand has been found to be the most active (IC50 10 mu g/ml) in this study. (C) 1997 Elsevier Science Ltd.

引用

页码：2165 / 2168

页数：4

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