Self-assembled mRNA vaccines

被引：417

作者：

Kim, Jeonghwan ^{[1
]}

Eygeris, Yulia ^{[1
]}

Gupta, Mohit ^{[1
]}

Sahay, Gaurav ^{[1
,2
,3
]}

机构：

[1] Oregon State Univ, Coll Pharm, Dept Pharmaceut Sci, Robertson Life Sci Bldg,2730 South Moody Ave, Portland, OR 97201 USA

[2] Oregon Hlth & Sci Univ, Dept Biomed Engn, Robertson Life Sci Bldg,2730 South Moody Ave, Portland, OR 97201 USA

[3] Oregon Hlth & Sci Univ, Casey Eye Inst, Dept Ophthalmol, Portland, OR 97239 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2021年 / 170卷

关键词：

mRNA delivery; Gene delivery; Lipid nanoparticles; Self-assembly; Immunization; COVID-19; LIPID NANOPARTICLE FORMULATIONS; ANTIGEN-PRESENTING CELLS; DENDRITIC CELLS; IN-VIVO; INTRACELLULAR DELIVERY; CATIONIC LIPIDS; SIRNA DELIVERY; POLY(ETHYLENE GLYCOL); CLINICAL CHARACTERISTICS; NEUTRALIZING ANTIBODIES;

D O I：

10.1016/j.addr.2020.12.014

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

mRNA vaccines have evolved from being a mere curiosity to emerging as COVID-19 vaccine front-runners. Recent advancements in the field of RNA technology, vaccinology, and nanotechnology have generated interest in delivering safe and effective mRNA therapeutics. In this review, we discuss design and self-assembly of mRNA vaccines. Self-assembly, a spontaneous organization of individual molecules, allows for design of nanoparticles with customizable properties. We highlight the materials commonly utilized to deliver mRNA, their physicochemical characteristics, and other relevant considerations, such as mRNA optimization, routes of administration, cellular fate, and immune activation, that are important for successful mRNA vaccination. We also examine the COVID-19 mRNA vaccines currently in clinical trials. mRNA vaccines are ready for the clinic, showing tremendous promise in the COVID-19 vaccine race, and have pushed the boundaries of gene therapy. ? 2020 Elsevier B.V. All rights reserved.

引用

页码：83 / 112

页数：30

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