Microparticles, thrombosis and cancer

被引：89

作者：

Aharon, Anat ^{[1
]}

Brenner, Benjamin ^{[2
,3
]}

机构：

[1] Rambam Hlth Care Campus, Thrombosis & Haemostasis Res Lab, IL-31096 Haifa, Israel

[2] Rambam Hlth Car Campus, Thrombosis & Haemostasis Unit, Haifa, Israel

[3] Technion Israel Inst Technol, Rappaport Fac Med, Haifa, Israel

来源：

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY | 2009年 / 22卷 / 01期

关键词：

microparticles; microvesicles; cancer; thrombosis; tissue factor; angiogenesis; PLATELET-DERIVED MICROPARTICLES; TISSUE FACTOR EXPRESSION; FACTOR-BEARING MICROPARTICLES; TUMOR-RELEASED MICROVESICLES; VASCULAR ENDOTHELIAL-CELLS; FAS LIGAND; VENOUS THROMBOEMBOLISM; MEMBRANE MICROPARTICLES; ACTIVATED PLATELETS; INDUCE ANGIOGENESIS;

D O I：

10.1016/j.beha.2008.11.002

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Microvesicles comprised of exosomes and microparticles are shed from both normal and malignant cells upon cell activation Or apoptosis. Microvesicles promote clot formation, mediate proinflammatory processes, facilitate cell-to-cell interactions, transfer proteins and mRNA to cells, and induce cell signalling. Micioparticles hearing tissue factor play a central role ill Coagulation initiation and thrombus formation. This chapter will review earlier studies which focus on the role of procoagulaut microvesicles in cancer thrombogenicity, and discuss the effects of microvesicles on vascular cell dysfunction and angiogenesis. In addition, this chapter will present new findings which characterize the haemostatic balance of microparticles, and Suggest a method that may potentially serve to predict a state of hypercoagulability in cancer patients. This chapter highlights the interplay between microvesicles, coagulation factors and cancer. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：61 / 69

页数：9

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