Solubility and preferential solvation of benzocaine in {methanol (1) + water (2)} mixtures at 298.15 K

被引：8

作者：

Cardenas, Zaira J. ^{[1
]}

Jimenez, Daniel M. ^{[1
]}

Almanza, Ovidio A. ^{[2
]}

Jouyban, Abolghasem ^{[3
,4
,5
]}

Martinez, Fleming ^{[1
]}

Acree, William E. ^{[6
]}

机构：

[1] Univ Nacl Colombia, Fac Ciencias, Dept Farm, Grp Invest Farmaceut Fisicoquim,Sede Bogota, Bogota, DC, Colombia

[2] Univ Nacl Colombia, Fac Ciencias, Dept Fis, Grp Fis Aplicada,Sede Bogota, Bogota, DC, Colombia

[3] Tabriz Univ Med Sci, Pharmaceut Anal Res Ctr, Tabriz, Iran

[4] Tabriz Univ Med Sci, Fac Pharm, Tabriz, Iran

[5] Tabriz Univ Med Sci, Kimia Idea Pardaz Azarbayjan KIPA Sci Based Co, Tabriz, Iran

[6] Univ North Texas, Dept Chem, Denton, TX USA

来源：

PHYSICS AND CHEMISTRY OF LIQUIDS | 2018年 / 56卷 / 04期

关键词：

Benzocaine; solubility; Jouyban-Acree model; inverse Kirkwood-Buff integrals; preferential solvation; PLUS WATER MIXTURES; JOUYBAN-ACREE MODEL; 298.15; K; PROPYLENE-GLYCOL; SOLVENT MIXTURES; THERMODYNAMIC PROPERTIES; COSOLVENT MIXTURES; TEMPERATURES; BINARY; DRUGS;

D O I：

10.1080/00319104.2017.1346651

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

The equilibrium solubility of benzocaine (BZC) in several {methanol (1) + water (2)} mixtures at 298.15K was determined. Solubility values are expressed in mole fraction and molarity and were calculated with the Jouyban-Acree model. Preferential solvation parameters of BZC by methanol (x(1,3)) were derived from their thermodynamic solution properties using the inverse Kirkwood-Buff integrals method. x(1,3) values are negative in water-rich mixtures (0.00<x(1)<0.32) but positive in the other mixtures (0.32 < x(1)<1.00). To explain the preferential solvation by water in the former case, it is conjecturable that the hydrophobic hydration around non-polar groups of BZC plays a relevant role in the solvation. Moreover, the higher solvation by methanol in mixtures of similar cosolvent compositions and methanol-rich mixtures could be explained in terms of the higher basic behaviour of methanol regarding water.

引用

页码：465 / 481

页数：17

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