Proteins, RNAs and chaperones in enzyme evolution: A folding perspective

被引：39

作者：

Csermely, P

机构：

[1] Department of Medical Chemistry, Semmelweis University, H-1444 Budapest

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1997年 / 22卷 / 05期

关键词：

D O I：

10.1016/S0968-0004(97)01026-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The present roles of RNA molecules as templates and of proteins as cellular catalysts may not have always been so clearly defined during evolution. Recent work on ribozymes shows that the catalytic activity of early RNAs may have been more general than previously thought, How did evolution select proteins, not RNA, to be the major biological catalysts? Why were chaperones necessary for the evolution of modern protein enzymes?

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页码：147 / 149

页数：3

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