Antigen Presentation by Extracellular Vesicles from Professional Antigen-Presenting Cells

被引：298

作者：

Lindenbergh, Marthe F. S. ^{[1
]}

Stoorvogel, Willem ^{[1
]}

机构：

[1] Univ Utrecht, Fac Vet Med, Dept Biochem & Cell Biol, NL-3508 TD Utrecht, Netherlands

来源：

ANNUAL REVIEW OF IMMUNOLOGY, VOL 36 | 2018年 / 36卷

关键词：

exosomes; microvesicles; MHC molecules; dendritic cells; B cells; T cells; MHC CLASS-II; CD4(+) T-CELLS; FOLLICULAR DENDRITIC CELLS; DC-DERIVED EXOSOMES; TUNNELING NANOTUBES; CROSS-PRESENTATION; PEPTIDE COMPLEXES; IMMUNE-RESPONSE; FAS LIGAND; B-CELLS;

D O I：

10.1146/annurev-immunol-041015-055700

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The initiation and maintenance of adaptive immunity require multifaceted modes of communication between different types of immune cells, including direct intercellular contact, secreted soluble signaling molecules, and extracellular vesicles (EVs). EVs can be formed as microvesicles directly pinched off from the plasma membrane or as exosomes secreted by multivesicular endosomes. Membrane receptors guide EVs to specific target cells, allowing directional transfer of specific and complex signaling cues. EVs are released by most, if not all, immune cells. Depending on the type and status of their originating cell, EVs may facilitate the initiation, expansion, maintenance, or silencing of adaptive immune responses. This review focusses on EVs from professional antigen-presenting cells, their demonstrated and speculated roles, and their potential for cancer immunotherapy.

引用

页码：435 / 459

页数：25

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