Synthesis and reactivity of palladium and platinum diimine complexes containing boronate esters

被引：11

作者：

King, AS

Nikolcheva, LG

Graves, CR

Kaminski, A

Vogels, CM

Hudson, RHE

Ireland, RJ

Duffy, SJ

Westcott, SA ^{[1
]}

机构：

[1] Mt Allison Univ, Dept Chem, Sackville, NB E4L 1G8, Canada

[2] Mt Allison Univ, Dept Biol & Biochem, Sackville, NB E4L 1G7, Canada

[3] Univ Western Ontario, Dept Chem, London, ON N6A 5B7, Canada

来源：

CANADIAN JOURNAL OF CHEMISTRY | 2002年 / 80卷 / 09期

关键词：

boronate esters; diazabutadienes; DNA-binding; platinum;

D O I：

10.1139/V02-145

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Condensation of alpha-diketones (2,3-butanedione, benzil, and acenaphthenequinone) with 3-H(2)NC(6)H(4)Bpin (pin = 1,2-O2C2Me4) gave the corresponding boron-containing alpha-diimines. The addition of these ligands to [MCl2(coe)](2) (coe = cis-cyclooctene, M = Pd or Pt) gave complexes of the type cis-MCl2(alpha-diimine) in moderate to high yields. The platinum complexes have been examined for their ability to bind to DNA using enzyme digest studies. These complexes were found to bind to single-stranded DNA as well as, or better than, the non-boron containing controls, and showed binding similar to that of cisplatin (cis-PtCl2(NH3)(2)).

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收藏

页码：1217 / 1222

页数：6

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